ATF4-Mediated Upregulation of REDD1 and Sestrin2 Suppresses mTORC1 Activity during Prolonged Leucine Deprivation
نویسندگان
چکیده
منابع مشابه
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.
Eukaryotic cells coordinate growth with the availability of nutrients through the mechanistic target of rapamycin complex 1 (mTORC1), a master growth regulator. Leucine is of particular importance and activates mTORC1 via the Rag guanosine triphosphatases and their regulators GATOR1 and GATOR2. Sestrin2 interacts with GATOR2 and is a leucine sensor. Here we present the 2.7 angstrom crystal stru...
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متن کاملmTORC1 Dependent Regulation of REDD1 Protein Stability
REDD1 is known to be transcriptionally upregulated in hypoxia. During hypoxic stress, REDD1 plays an important role as a mediator of mTORC1 inhibition. REDD1 is also subject to highly dynamic transcriptional regulation in response to a variety of other stress signals. In addition, the REDD1 protein is highly unstable. However, it is currently not well understood how REDD1 protein stability is r...
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ژورنال
عنوان ژورنال: The Journal of Nutrition
سال: 2019
ISSN: 0022-3166,1541-6100
DOI: 10.1093/jn/nxz309